Most survival analysis models for time-to-event data, like Cox regression, assume independence. The survival time for one individual cannot influence the survival time for another.
This assumption doesn’t hold in many study designs. You may have animals clustered into litters, matched pairs, or patients in a multi-center trial with correlated survival times within a center.
In frailty models, you can introduce frailty terms, similar to the random effects in linear mixed models. In this webinar you will learn how to implement a frailty analysis, address some of the complications involved, and discuss alternative approaches.
Note: This training is an exclusive benefit to members of the Statistically Speaking Membership Program and part of the Stat’s Amore Trainings Series. Each Stat’s Amore Training is approximately 90 minutes long.
About the Instructor
Steve Simon works as an independent statistical consultant and as a part-time faculty member in the Department of Biomedical and Health Informatics at the University of Missouri-Kansas City. He has previously worked at Children’s Mercy Hospital, the National Institute for Occupational Safety and Health, and Bowling Green State University.
Steve has over 90 peer-reviewed publications, four of which have won major awards. He has written one book, Statistical Evidence in Medical Trials, and is the author of a major website about Statistics, Research Design, and Evidence Based Medicine, www.pmean.com. One of his current areas of interest is using Bayesian models to forecast patient accrual in clinical trials. Steve received a Ph.D. in Statistics from the University of Iowa in 1982.
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