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Parametric or Semi-Parametric Models in Survival Analysis?

August 13th, 2018 by

It was Casey Stengel who offered the sage advice, “If you come to a fork in the road, take it.”

When you need to fit a regression model to survival data, you have to take a fork in the road. One road asks you to make a distributional assumption about your data and the other does not. (more…)


Member Training: Power Analysis and Sample Size Determination Using Simulation

July 30th, 2018 by
This webinar will show you strategies and steps for using simulations to estimate sample size and power. You will learn:
  • A review of basic concepts of statistical power and effect size
  • A simulation-based approach to power analysis
  • An overview of how to implement simulations in various popular software programs.

What is Survival Analysis and When Can It Be Used?

July 17th, 2018 by

by Steve Simon, PhD

There are two features of survival models.

First is the process of measuring the time in a sample of people, animals, or machines until a specific event occurs. In fact, many people use the term “time to event analysis” or “event history analysis” instead of “survival analysis” to emphasize the broad range of areas where you can apply these techniques.

Second is the recognition that not everyone/everything in your sample will experience the event. Those not experiencing the event, either because the study ended before they had the event or because they were lost to follow-up, are classified as censored observations.

(more…)


Member Training: Adjustments for Multiple Testing: When and How to Handle Multiplicity

May 3rd, 2018 by
 A research study rarely involves just one single statistical test. And multiple testing can result in more statistically significant findings just by chance.

After all, with the typical Type I error rate of 5% used in most tests, we are allowing ourselves to “get lucky” 1 in 20 times for each test.  When you figure out the probability of Type I error across all the tests, that probability skyrockets.
(more…)


Member Training: Equivalence Tests and Non-Inferiority

April 2nd, 2018 by
Statistics is, to a large extent, a science of comparison. You are trying to test whether one group is bigger, faster, or smarter than another.
 
You do this by setting up a null hypothesis that your two groups have equal means or proportions and an alternative hypothesis that one group is “better” than the other. The test has interesting results only when the data you collect ends up rejecting the null hypothesis.
 
But there are times when the interesting research question you’re asking is not about whether one group is better than the other, but whether the two groups are equivalent.

(more…)


Member Training: Using Transformations to Improve Your Linear Regression Model

March 5th, 2018 by

Transformations don’t always help, but when they do, they can improve your linear regression model in several ways simultaneously.

They can help you better meet the linear regression assumptions of normality and homoscedascity (i.e., equal variances). They also can help avoid some of the artifacts caused by boundary limits in your dependent variable — and sometimes even remove a difficult-to-interpret interaction.

(more…)